A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
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Utilizing one-molecule optical and AFM imaging and pressure-spectroscopy tactics, we look for to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our investigation interests include:
1996, 1st mesoscopic demand density waves devices; and 1st electrical measurements on only one metal nanocluster amongst nanoelectrodes
‘It had been merely a matter of buying up a reserve on mobile biology and starting to browse. I'd come from a environment of extremely-large vacuums, cryostats and quantum phenomena, and now I had been Performing at area temperature with molecular biology kits.
Sculpting nano-electrodes which has a transmission electron beam for electrical and geometrical characterization of nanoparticles.
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and to start with at any time study with the dynamics DNA supercoils and the discovery of supercoil hopping
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of a single wire bridging two electrodes
What distinguishes biology from chemistry is the fact these elements alongside one another make up a residing procedure. The key of reported daily life, I do think, lies while in the interactions, the interaction of All those molecules. The big problem concerning the origin of everyday living is still unanswered. How did we at any time evolve from simple molecules to the exceptionally sophisticated units we see these days? We don't know. I need to work on These types of huge, open issues.’
Circulation-pushed rotary motors for instance windmills and water wheels drive practical processes in human Culture. Whilst examples of this kind of rotary motors also attribute prominently in mobile biology, their artificial development within the nanoscale has remained challenging. Right here we exhibit circulation-pushed rotary movement cees dekker of the self-arranged DNA nanostructure that is definitely docked on to a nanopore in a skinny good-state membrane. An elastic DNA bundle self-assembles into a chiral conformation upon phoretic docking on to the stable-point out nanopore, and subsequently shows a sustained unidirectional rotary movement of up to twenty rev s−one.
2003, shown the 1st biosensors designed away from a carbon nanotube; settled the construction and mechanism of DNA maintenance proteins; and discovery of a completely new procedure for fabricating stable-condition nanopores for DNA translocation
Bulk-floor coupling identifies the mechanistic relationship between Min-protein patterns in vivo and in vitro
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Mother nature Physics thanks the nameless reviewers for their contribution to the peer critique of this work.
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Instance (two) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim on the pore is highlighted in red, plus a 3D rendering of the movement of the DNA rod is shown.